HNBGU Srinagar Uttarakhand (M.Sc. Biotechnology 3rd Sem)
Paper-II Bioinformatics and Biostatistics
(Course Code: SOLS/MBT/DSC-8)
No. of Credits: 5
UNIT-I (Cr- 1)
Introduction to bioinformatics: Objectives, applications, and scopes of information technology in
biology, bioinformatics resources, Word wide web, and web browsers.
Biological databases: Primary, secondary database, GENBANK, EMBL, DDBJ, PDB, and UNIPROT.
Search engines: Entrez, SRS, web server-NCBI, and EBI.
UNIT- II (Cr- 1)
Sequence alignment: Definition and applications,
Sequence similarity searching tools: FASTA, and BLAST, multiple sequence alignment (MSA) and
applications, software and tools for MSA, phylogenetic analysis, tools for phylogenetic analysis
and their applications.
UNIT- III (Cr- 1)
Protein structure: Prediction tools, molecular modeling (Homology modeling), visualization
tools, protein-protein interactions and online tools for prediction.
UNIT–IV (Cr- 1)
Biostatistics and its importance in biological research.
Types of data and analysis: Qualitative vs. quantitative, discrete vs. continuous, primary and
secondary data, methods of data collection, graphical representation of data.
UNIT-V (Cr- 1)
Statistical methods: Mean, mode, median, standard error, standard deviation, basics of
probability theory, skewness & kurtosis, correlation & regression.
Statistical data calculation using computational tools.
Recommended Books:
1. Pasha, C., Swathi, Rajan A. Bioinformatics & Biostatistics. 2021. 1st ed. Divya Lakshmi
Publishers.
2. Arumugam, N., Gopi, A. Mumaresan, V., Meena, A., Sundaralingam, R. Biostatistics, Computer
Application and Bioinformatics. 2019. 4th ed. Saras Publication.
3. Lesk, A.M. Introduction to Bioinformatics. 2019. 5th ed. Wiley Publications
4. Rastogi, S.C., Mendiratta, N., Rastogi, P. Bioinformatics: Methods and Applications—
Genomics, Proteomics, and Drug Discovery. 2013. 4th ed. Prentice Hall of India Private Ltd.
5. Balagurusamy, E. Fundamentals of Computers. 2008. 1st ed. Tata McGraw Hill.
6. Pevsner, J. Bioinformatics and functional genomics (3rd ed.), 2015. Wiley-Blackwell.