Methylotrophy C1 Metabolism, Methanotrophy, Energetics

Methylotrophy is the metabolic ability of certain microorganisms to utilize reduced one-carbon (C1) compounds (without C–C bonds) as their sole source of carbon and energy.

Common C1 substrates:

• Methane (CH₄)
• Methanol (CH₃OH)
• Formaldehyde (CH₂O)
• Formate (HCOO⁻)
• Methylated amines

Microbial Physiology and Metabolism