Methanogenesis in archaea: Biochemistry  Coenzymes (F₄₂₀ coenzyme M) and regulation

Methanogenesis in archaea: Biochemistry Coenzymes (F₄₂₀ coenzyme M) and regulation

April 24, 2026

Methanogenesis in archaea: Biochemistry, coenzymes (F₄₂₀ coenzyme M) and regulation

1) Methanogenesis

  • Methanogenesis is a unique anaerobic respiratory process that produces methane as its metabolic product.
  • Methanogens are strictly anaerobic archaea capable of producing methane.

Key features:

  • Strictly anaerobic.
  • Final step in anaerobic decomposition.
  • Uses unusual coenzymes such as Coenzyme F₄₂₀, Coenzyme M, Methanofuran and H₄MPT.
  • Low energy yield.
  • Produces ATP via H+ or Na+ gradients.

Unique to Archaea and contribute to the global methane cycle.

Microbial Physiology and Metabolism

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