Enzyme V(II)​  Catalytic Mechanisms II: Metal Ion catalysis; Catalysis by ​Approximation, Strain and distortion​

Enzyme V(II)​ Catalytic Mechanisms II: Metal Ion catalysis; Catalysis by ​Approximation, Strain and distortion​

March 7, 2022

Enzyme V(II) Catalytic Mechanisms II: Metal Ion catalysis; Catalysis by Approximation, Strain and distortion

Once a substrate is bound to an enzyme, properly positioned catalytic functional groups aids in the cleavage and formation of bonds by a variety of mechanisms, including:

Metal ion catalysis 

  • Nearly a third of all known enzymes require one or more metal ions for catalytic activity
  • Metals, either as prosthetic group tightly bind to the enzyme or as transiently bind to the enzyme at the time of reaction can participate in catalysis in several ways:
    • Metal ions can serve as electrophilic catalyst, stabilizing negative charge on a reaction intermediate.
    • Stabilize transition state and reactive intermediates.
    • Act much like a proton but can be present in high concentration at neutral pH and can have multiple positive charges.
    • Help to generate strong nucleophile  group.
    • Bind to substrates to insure proper orientation.
    • Metals can mediate oxidation-reduction reactions by reversible changes in the metal ion’s oxidation state.

2 responses to “Enzyme V(II)​ Catalytic Mechanisms II: Metal Ion catalysis; Catalysis by ​Approximation, Strain and distortion​”

  1. Kalyani semwal says:

    It is very helpful 😊 thank you

  2. […] Enzyme V(II)​ Catalytic Mechanisms II: Metal Ion catalysis; Catalysis by ​Approximation, Strain … […]

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