Citric acid cycle,​ Its function in energy generation and providing precursors for biosynthetic pathways; Anaplerotic reactions ​ ​

Citric acid cycle,​ Its function in energy generation and providing precursors for biosynthetic pathways; Anaplerotic reactions ​ ​

March 18, 2022

Carbohydrate catabolism II: Citric acid cycle,Its function in energy generation and providing precursors for biosynthetic pathways; Anaplerotic reactions 
Tricarboxylic acid (TCA) also known as Citric acid cycle or Krebs cycle.

  • Discovered in 1937 by Hans Adolf Krebs for which he received the Nobel Prize for Physiology and Medicine (1953).
  • A series of eight chemical reactions occurs in all the aerobic organism to generate energy through the oxidation of acetyl- CoA derived from carbohydrates fats and proteins into carbon dioxide, reducing equivalents (FADH2 and NADH+H+) and chemical energy in the form of GTP.
  • Operates in the mitochondrial matrix.
  • Strictly oxygen dependent
  • Hub in metabolism, with degradative pathways leading in and anabolic pathways leading out.
  • Closely regulated in coordination with other pathways

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