Oxidative Phosphorylation III: ATP synthase, Structure and Mechanism of action ATP synthesis, P/O ratio
Oxidative Phosphorylation III: ATP synthase: Structure and Mechanism of ATP synthesis, P/O ratio
- Mitochondrial ATP synthase, also known as Complex V is a F-type ATPase.
- ATP synthase is a remarkable molecular machine. It is an enzyme, a proton pump, and a rotating molecular motor. Nearly all the ATP that fuels our cellular processes is made by this ATP synthase.
- It resemble in structure and mechanism to the ATP synthases of chloroplasts and bacteria.
- Located in inner mitochondrial membrane catalyzes the formation of ATP from ADP and Pi, accompanied by the flow of protons from the P (intermembrane space) to the N (matrix) side of the membrane.
- It consist of two multi-protein components:
- F1, a peripheral membrane protein
- Fo (o denoting oligomycin-sensitive), an integral multi-transmembrane protein complex is a proton channel.