Reverse transcription

Reverse transcription

January 1, 2022

Reverse Transcription

RNA dependent synthesis of DNA is known as reverse transcription.

  1. Reverse transcription is an important step in the life cycle of RNA viruses including retroviruses.
  2. The RNA viruses contain an enzyme reverse transcriptase that convert their RNA genome into duplex DNA.
  3. The resulting duplex DNA often becomes incorporated into the genome of the eukaryotic host cell.
  4. These integrated (and dormant) viral genes can be activated and transcribed, and the gene products—viral proteins and the viral RNA genome itself—packaged as new viruses.
  5. Reverse transcriptase was discovered in 1970 by David Baltimore, Howard Temin, and Satoshi Mizutani

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