Regulatory Strategies II:​ Zymogen activation, Digestive Proteases; Fibrinogen and Prothrombin​;  Reversible Covalent Modification​: (Phosphorylation with special reference to Glycogen phosphorylase​)

Regulatory Strategies II:​ Zymogen activation, Digestive Proteases; Fibrinogen and Prothrombin​; Reversible Covalent Modification​: (Phosphorylation with special reference to Glycogen phosphorylase​)

March 11, 2022

Regulatory Strategies II: Proteolytic activation (Zymogen activation)(Digestive Proteases; Fibrinogen; Prothrombin); Reversible Covalent Modification (Phosphorylation with special reference of Glycogen phosphorylase

The catalytic activity of the proteins is regulated in four principal ways:

  • Allosteric control
  • Multiple forms of enzymes (Isoenzymes)
  • Proteolytic activation (Zymogen activation)
  • Reversible covalent modification

Zymogens and their activation

  • Many enzymes are activated by the hydrolysis of a few or even one peptide bond in inactive precursors called zymogens or proenzymes.​
  • Zymogen activation do not require ATP hydrolysis.
  • Important mode of regulation for both extracellular and intracellular enzyme
  • The activation of zymogen is an irreversible reaction.
  • The digestive enzymes that hydrolyze proteins are synthesized as zymogens in the stomach and pancreas 
  • Blood clotting is mediated by a cascade of proteolytic activations that ensures a rapid and amplified response to trauma.

 

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