Allosteric Control of enzymes and Isozymes/Isoenzymes Lactate dehydrogenase)
Allosteric Control of enzymes: Feedback Inhibition; Properties of Allosteric control; Models for Allosteric regulation: The Symmetry Model (MWC model); The Sequential Model (KNF model); Allosteric regulation of Aspartate Transcarbomylase (ATCase);
Different forms of enzymes (Isozymes/Isoenzymes) Lactate dehydrogenase
- In cells, thousands of catabolic and anabolic reactions are continuously being taking place. Almost all the metabolic reactions are catalyzed by Enzymes.
- Many metabolic intermediates have catabolic as well as anabolic roles. These intermediates channeled to different metabolic fate meet the demand of cells
- To control the catabolic and anabolic pathways according to the needs of cells in time and space, cell adapts various regulatory strategies which sense the transitory needs of the cell and adjust the catalytic activities of enzymes accordingly.
- These catalytic strategies ensures the harmonious integration of the diverse reactions of metabolism according to the time and space.
The catalytic activity of the proteins is regulated in four principal ways:
- Allosteric control
- Multiple forms of enzymes (Isoenzymes)
- Reversible covalent modification
- Proteolytic activation (Zymogen activation)