Gluconeogenesis: Reactions and the Key enzymes of gluconeogenesis Regulation of gluconeogenesis and Cori cycle
Gluconeogenesis: Non-carbohydrate precursors of glucose; Reactions and the Key enzymes of gluconeogenesis (Pyruvate carboxylase, PEP carboxykinase, Fructose-1,6-bisphosphatase and Glucose-6 phosphatase); Regulation of gluconeogenesis and Cori cycle
- Gluconeogenesis occurs in all animals, plants, fungi, and microorganism
- In mammals, the major site of Gluconeogenesis is the Liver (90% glucose synthesis) and minor site is kidney (10%).
- It helps to maintain the blood glucose level during prolonged starvation.
- The major noncarbohydrate precursors are pyruvate, lactate, alanine, oxaloacetate, dihydroxyacetone phosphate. , glycerol and several glucogenic amino acids.
- Gluconeogenesis is not the reversal of glycolysis