Enzyme IV: Enzyme inhibition; Reversible (Competitive, Noncompetitive and Uncompetitive) and Irreversible inhibition of enzymes
Enzyme IV: Enzyme inhibition; Reversible (Competitive, Noncompetitive and Uncompetitive) and Irreversible inhibition of enzymes
- Enzyme inhibitors are molecules that interfere with catalysis, slowing or halting enzymatic reactions.
- Almost all the cellular processes are catalyze by the enzymes, therefore the use of enzyme inhibitors are among the most important pharmaceutical agents to understand and modify the cellular process.
- For example aspirin (acetylsalicylate) inhibits the enzyme that catalyzes the first step in the synthesis of prostaglandins which are the mediators of inflammation and pain.
- The study of enzyme inhibitors also has provided valuable information about enzyme mechanisms and has helped define some metabolic pathways.
Types of Inhibitions
- Reversible Inhibition
- Irreversible inhibition
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